The Cooperative Human Linkage Center (CHLC) was a federally funded genome center under the direction of Jeffrey C. Murray, M.D.

The Cooperative Human Linkage Center developed a variety of high heterozygosity genetic maps that are greatly enriched for the presence of easy-to-use PCR-formatted microsatellite markers. Particular emphasis was placed on the inclusion of tri- and tetranucleotide repeats that are easy to genotype. The center also synthesized published genotypic data developed on the CEPH families by outside investigators, as well as genotypic information generated from marker development in CHLC core laboratories.

The following projects and facilities were part of this effort:

• Clone Generation, Geoffrey M. Duyk, M.D.,PhD. Principal Investigator.
  
• Sequencing and Marker Evaluation, Val C. Sheffield, M.D.,Ph.D., Principal Investigator.
  
• Marker Typing, Jeffrey C. Murray, M.D. and James L. Weber, Ph.D.,Co-Principal Investigators.
  
• Mapping and Diagnostics, Kenneth H. Buetow, Ph.D.,Principal Investigator.
  
• Informatics Support, Kenneth H. Buetow, Ph.D.,Director.
  

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